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1

Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship

Domagala, John M., Bridges, Alex J., Culbertson, Townley P., Gambino, Laura, Hagen, Susan E., Karrick, Gregory, Porter, Kenneth, Sanchez, Joseph P., Sesnie, Josephine A.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1991

2

Discovery and optimization of nonpeptide HIV-1 protease inhibitors

Peter J. Tummino, J.V.N. Vara Prasad, Donna Ferguson, Carolyn Nouhan, Neil Graham, John M. Domagala, Edmund Ellsworth, Christopher Gajda, Susan E. Hagen, Elizabeth A. Lunney, Kimberly S. Para, Bradley

Journal:

Bioorganic & Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 779 KB

english, 1996

3

Novel Benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring

Harriet W Hamilton, Gisele Nishiguchi, Susan E Hagen, John D Domagala, Peter C Weber, Stephen Gracheck, Stefanie L Boulware, Eric C Nordby, Hidetsura Cho, Takeshi Nakamura, Satoru Ikeda, Wataru Watana

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 102 KB

english, 2002

4

Nonpeptidic HIV protease inhibitors: 6-alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties

J.V.N. Vara Prasad, Fred E. Boyer, John M. Domagala, Edmund L. Ellsworth, Christopher Gajda, Susan E. Hagen, Larry J. Markoski, Bradley D. Tait, Elizabeth A. Lunney, Peter J. Tummino, Donna Ferguson,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 335 KB

english, 1999

5

4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme

Edmund L. Ellsworth, John Domagala, J.V.N. Vara Prasad, Susan Hagen, Donna Ferguson, Tod Holler, Donald Hupe, Neil Graham, Caroline Nouhan, Peter J. Tummino, Greg Zeikus, Elizabeth A. Lunney

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 342 KB

english, 1999

6

Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety

J.V.N Vara Prasad, Larry J Markoski, Fred E Boyer, John M Domagala, Edmund L Ellsworth, Christopher Gajda, Susan E Hagen, Bradley D Tait, Elizabeth A Lunney, Peter J Tummino, Donna Ferguson, Tod Holle

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 336 KB

english, 1999

7

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor

J.V.N. Vara Prasad, Frederick E. Boyer, John M. Domagala, Edmund L. Ellsworth, Christopher Gajda, Harriet W. Hamilton, Susan E. Hagen, Larry J. Markoski, Bruce A. Steinbaugh, Bradley D. Tait, Christin

Journal:

Bioorganic & Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 468 KB

english, 1999

8

4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV Protease: The Effect of Heterocyclic Substituents at C-6 on Antiviral Potency and Pharmacokinetic Parameters

Hagen, Susan E., Domagala, John, Gajda, Christopher, Lovdahl, Michael, Tait, Bradley D., Wise, Eric, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Urumov, Andrej

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 200 KB

english, 2001

9

Synthesis of 5-methyl-4-oxo-quinolinecarboxylic acids

Susan E. Hagen, John M. Domagala

Journal:

Journal of Heterocyclic Chemistry

Année:

1990

Fichier:

PDF, 629 KB

1990

10

Discharge Vital Signs: An Enhancement to ED Quality and Patient Outcomes

Susan E. Domagala

Journal:

Journal of Emergency Nursing

Année:

2009

Langue:

english

Fichier:

PDF, 103 KB

english, 2009

11

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids

Sanchez, Joseph P., Domagala, John M., Hagen, Susan E., Heifetz, Carl L., Hutt, Marland P., Nichols, Jeffry B., Trehan, Ashok K.

Journal:

Journal of Medicinal Chemistry

Année:

1988

Langue:

english

Fichier:

PDF, 1.07 MB

english, 1988

12

New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids

Hagen, Susan E., Domagala, John M., Heifetz, Carl L., Sanchez, Joseph P., Solomon, Marjorie

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 833 KB

english, 1990

13

A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs

Lunney, Elizabeth A., Hagen, Susan E., Domagala, John M., Humblet, Christine, Kosinski, Janet, Tait, Bradley D., Warmus, Joseph S., Wilson, Michael, Ferguson, Donna

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 5.17 MB

english, 1994

14

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy

Domagala, John M., Hagen, Susan E., Joannides, Themis, Kiely, John S., Laborde, Edgardo, Schroeder, Mel C., Sesnie, Josephine A., Shapiro, Martin A., Suto, Mark J., Vanderroest, Steven

Journal:

Journal of Medicinal Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 1.31 MB

english, 1993

15

5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease

Boyer, Frederick E., Vara Prasad, J. V. N., Domagala, John M., Ellsworth, Edmund L., Gajda, Christopher, Hagen, Susan E., Markoski, Larry J., Tait, Bradley D., Lunney, Elizabeth A., Palovsky, Alexande

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 428 KB

english, 2000

16

Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids

Hagen, Susan E., Domagala, John M., Heifetz, Carl L., Johnson, Judith

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 722 KB

english, 1991

17

4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease

Tait, Bradley D., Hagen, Susan, Domagala, John, Ellsworth, Edmund L., Gajda, Christopher, Hamilton, Harriet W., Vara Prasad, J. V. N., Ferguson, Donna, Graham, Neil, Hupe, Donald, Nouhan, Carolyn, Tum

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 330 KB

english, 1997

18

Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential

Hagen, Susan E., Domagala, John M., Gracheck, Stephen J., Sesnie, Josephine A., Stier, Michael A., Suto, Mark J.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 826 KB

english, 1994

19

Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity

Hagen, Susan E., Vara Prasad, J. V. N., Boyer, Frederick E., Domagala, John M., Ellsworth, Edmund L., Gajda, Christopher, Hamilton, Harriet W., Markoski, Larry J., Steinbaugh, Bruce A., Tait, Bradley

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 157 KB

english, 1997

20

7-Substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials

Domagala, John M., Hagen, Susan E., Heifetz, Carl L., Hutt, Marland P., Mich, Thomas F., Sanchez, Joseph P., Trehan, Ashok K.

Journal:

Journal of Medicinal Chemistry

Année:

1988

Langue:

english

Fichier:

PDF, 520 KB

english, 1988

21

Emergency Nursing Triage: Keeping It Safe

Domagala, Susan E., Vets, Jessica

Journal:

Journal of Emergency Nursing

Année:

2015

Langue:

english

Fichier:

PDF, 476 KB

english, 2015

22

Capacity for change

Domagala, Susan E., Rowles, Connie J.

Journal:

Nursing Management (Springhouse)

Année:

2002

Langue:

english

Fichier:

PDF, 189 KB

english, 2002

23

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibα

CRANMER, Susan L., PIKOVSKI, Inna, MANGIN, Pierre, THOMPSON, Philip E., DOMAGALA, Teresa, FRAZZETTO, Mark, SALEM, Hatem H., JACKSON, Shaun P.

Journal:

Biochemical Journal

Année:

2005

Langue:

english

Fichier:

PDF, 390 KB

english, 2005